A study conducted at the Grenoble Institute of Neurosciences shows that several proteins associated with Alzheimer's disease can be detected in mouse stool samples and that some of these markers show changes at a very early stage, even before the amyloid plaques characteristic of the disease become detectable in the brain. Published in Scientific Reports, these findings open up a new avenue of research towards simple, non-invasive testing methods, whose relevance must now be evaluated in humans.
Two studies conducted at the Grenoble Institute of Neuroscience as part of Clarissa Baratin’s PhD research and published in Nature Communications show that our brain does not rely on exactly the same neural circuits to evaluate pleasant and unpleasant experiences, and that its activity immediately before a decision can influence our choices.
Doubting what we have seen, what we have done, or a decision we have just made: doubt is a prominent feature of obsessive-compulsive disorder (OCD). A study conducted at the Grenoble Institute of Neuroscience suggests that this doubt may not result from poorer visual perception, but could instead be linked to altered metacognition, the ability to evaluate one’s own perceptions.
A study conducted at the Grenoble Institute of Neuroscience shows, in a progressive macaque model of Parkinson’s disease, that activity in the subthalamic nucleus changes before the onset of motivational, cognitive and then motor impairments. These findings could pave the way for deep brain stimulation strategies better tailored to each patient’s symptoms.
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A study conducted at the Grenoble Institute of Neurosciences shows that several proteins associated with Alzheimer's disease can be detected in mouse stool samples and that some of these markers show changes at a very early stage, even before the amyloid plaques characteristic of the disease become detectable in the brain. Published in Scientific Reports, these findings open up a new avenue of research towards simple, non-invasive testing methods, whose relevance must now be evaluated in humans.
Dans le dernier numéro d'Inserm, le magazine, Homaira Nawabi et Stéphane Belin, chercheurs Inserm au Grenoble Institut des Neurosciences, décryptent une approche innovante qui pourrait ouvrir de nouvelles perspectives pour la réparation du système nerveux central.
Two studies conducted at the Grenoble Institute of Neuroscience as part of Clarissa Baratin’s PhD research and published in Nature Communications show that our brain does not rely on exactly the same neural circuits to evaluate pleasant and unpleasant experiences, and that its activity immediately before a decision can influence our choices.
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Nature Communications vol. 16, Article number: 9218 (2025) - Synchrotron-generated microbeams as a radiosurgical alternative for drug-resistant epilepsies: Proof of concept in a mouse model of mesiotemporal lobe epilepsy
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Epilepsia. 2025 Dec 23. doi: 10.1002/epi.70063. Online ahead of print - L-Dopa-modified microtubules lead to synapse instability in cultured neurons: possible implications in Parkinson’s disease therapy
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