Two recent studies conducted by GIN researchers reveal new cognitive mechanisms involved in the often ‘silent’ dimensions of schizophrenia.
A collaborative French-Swiss study reveals a previously unknown role for astrocytes in the brain's information processing. Published in the journal Cell, the research shows that these glial cells are capable of integrating signals from several neurons at once—a conceptual shift in our understanding of the brain.
By observing the behaviour of mice with mesiotemporal epilepsy, researchers at GIN have confirmed the relevance of this mouse model for studying both epilepsy and its comorbidities.
Alzheimer
Giving neurons a second youth: Leticia Peris's approach to combating Alzheimer's disease
On September 11, 2025
Awarded of the Alzheimer's Foundation's 2024 ‘Innovative Programmes’ call for projects, Leticia Peris, an Inserm researcher at GIN, is studying the combined effects of toxic amyloid and Tau proteins implicatedin Alzheimer's disease. Her ambition is to strengthen neural connections in order to preserve cognitive functions.
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Two recent studies conducted by GIN researchers reveal new cognitive mechanisms involved in the often ‘silent’ dimensions of schizophrenia.
A collaborative French-Swiss study reveals a previously unknown role for astrocytes in the brain's information processing. Published in the journal Cell, the research shows that these glial cells are capable of integrating signals from several neurons at once—a conceptual shift in our understanding of the brain.
By observing the behaviour of mice with mesiotemporal epilepsy, researchers at GIN have confirmed the relevance of this mouse model for studying both epilepsy and its comorbidities.
Latest publications
- Characterizing early auditory deficits in schizophrenia using drift-diffusion modeling.
Dondé C, Pereira M, Nalborczyk L, Roux P, Faivre N, Brunelin J.
Schizophr Res. 2025 Jul 29;284:23-31. doi: 10.1016/j.schres.2025.07.024. Online ahead of print. PMID: 40737765 - Impaired effort allocation in schizophrenia
Blouzard E, Cignetti F, Meyniel F, Pouchon A, Polosan M, Bastin J, Dondé C.
Schizophr Res Cogn. 2025 Jul 15;42:100378. doi: 10.1016/j.scog.2025.100378. eCollection 2025 Dec. PMID: 40697646 Free PMC article. - Astrocytes functionally integrate multiple synapses via specialized leaflet domains.
Lucas Benoit, Ines Hristovska, Nicolas Liaudet, Pierre-Henri Jouneau, Arnold Fertin, Roberta de Ceglia, David Litvin, Maria Amalia Di Castro, Milica Jevtic, Ioannis Zalachoras, Toko Kikuchi, Ludovic Telley, Matteo Bergami, Yves Usson, Chihiro Hisatsune, Katsuhiko Mikoshiba, Karin Pernet-Gallay, Andrea Volterra
Cell, published online September 24, 2025 DOI 10.1016/j.cell.2025.08.036 - Comorbidities in the mouse model of temporal lobe epilepsy induced by intrahippocampal kainate.
Samalens L, Beets C, Courivaud C, Kahane P, Depaulis A.
Epilepsia. 2025 Jul 17. doi: 10.1111/epi.18553. Online ahead of print. - Subcortical correlates of consciousness with human single neuron recordings
Michael Pereira, Nathan Faivre, Fosco Bernasconi, Nicholas Brandmeir , Jacob E Suffridge, Kaylee Tran, Shuo Wang , Victor Finomore, Peter Konrad , Ali Rezai, Olaf Blanke
Elife. 2025 May 22:13:RP95272. doi: 10.7554/eLife.95272. - The Mn-motif protein MAP6d1 assembles ciliary doublet microtubules.
Dharshini Gopal, Juliette Wu, Julie Delaroche, Christophe Bosc, Manon De Andrade, Eric Denarier, Gregory Effantin, Annie Andrieux, Sylvie Gory-Fauré, Laurence Serre & Isabelle Arnal
Nature Communications, 2025, 16 (1), pp.6210. (10.1038/s41467-025-61679-0) - Relaxometry and contrast-free cerebral microvascular quantification using balanced steady-state free precession MR fingerprinting.
Coudert T, Delphin A, Barrier A, Legris L, Warnking JM, Lamalle L, Doneva M, Lemasson B, Barbier EL, Christen T.
Magn Reson Med. 2025 Jul;94(1):302-316. doi: 10.1002/mrm.30434. Epub 2025 Jan 17.