Eq M.Decressac
Leigh syndrome: Ultrasound-assisted gene therapy, a promising strategy
On March 3, 2026
In a paper published in Brain, the team led by Michael Decressac succeeded in restoring the expression of the NDUFS4 gene in a mouse model of Leigh syndrome using ultrasound-assisted gene therapy. This innovative approach was associated with significant benefits in terms of survival and brain function in the treated animals.
A team from the Grenoble Institute of Neurosciences has developed an extremely simple, biomimetic artificial neural network capable of automatically identifying complex temporal patterns in multichannel neural signals. This original approach offers a solution for real-time processing of the massive data streams generated by next-generation neural interfaces.
Epilepsie
X-ray microbeams to treat drug-resistant epilepsy: a promising proof of concept
On January 20, 2026
In a study published at the end of 2025 in the journal Epilepsia, a GIN research team shows, in a mouse model, that X-ray microbeams can significantly reduce epileptic activity while limiting side effects on surrounding brain tissue.
A major discovery made at GIN, which opens up new avenues for understanding the long-term side effects of this essential treatment.
Events
News
Communiqué, Conférence, Rencontre / Débat
Semaine du Cerveau 2026 : Plongée dans un cerveau "trop bavard" avec les scientifiques du GIN
On April 1, 2026
"De l’écho au chaos, quand le cerveau en dit trop" était le titre de la soirée Semaine du Cerveau organisée au GIN le 20 mars 2026. Une soirée qui a mobilisé une dizaine de jeunes scientifiques du GIN autour de thématiques complexes qu’ils ont su vulgariser avec humour et pédagogie.
Communiqué, Rencontre / Débat
Semaine du Cerveau 2026 : Regards croisés entre neurologie et psychiatrie sur les troubles du langage
On March 27, 2026
Jeudi 19 mars 2026, dans le cadre de la Semaine du Cerveau, une soirée consacrée aux troubles du langage était organisée au CHU Grenoble Alpes, avec plusieurs chercheurs du GIN.
In a paper published in Brain, the team led by Michael Decressac succeeded in restoring the expression of the NDUFS4 gene in a mouse model of Leigh syndrome using ultrasound-assisted gene therapy. This innovative approach was associated with significant benefits in terms of survival and brain function in the treated animals.
Latest publications
- Ultrasound-assisted gene therapy mitigates Leigh syndrome pathology
Mathilde Faideau, Romain Clément, Sébastien Rigollet, Giorgia Benegiamo, Cassandra Cresson, Béatrice Blot, Robin Reynaud-Dulaurier, Sara Yjjou, Fanny Aprahamian, Sylvère Durand, Anthony Delalande, Emmanuel L Barbier, Vasile Stupar, Johan Auwerx, Michael Decressac
Brain,2026 Jan 23. doi: 10.1093/brain/awag026. - A frugal Spiking Neural Network for unsupervised multivariate temporal pattern classification and multichannel spike sorting
Sai Deepesh Pokala, Marie Bernert, Takuya Nanami, Takashi Kohno, Timothée Lévi & Blaise Yvert
Nature Communications vol. 16, Article number: 9218 (2025) - Synchrotron-generated microbeams as a radiosurgical alternative for drug-resistant epilepsies: Proof of concept in a mouse model of mesiotemporal lobe epilepsy
Loan Samalens, Camille Beets, Clothilde Courivaud, Sarvenaz Keshmiri, Jean-François Adam, Paolo Pellicioli, Emmanuel Luc Barbier, Raphaël Serduc, Antoine Depaulis
Epilepsia. 2025 Dec 23. doi: 10.1002/epi.70063. Online ahead of print - L-Dopa-modified microtubules lead to synapse instability in cultured neurons: possible implications in Parkinson’s disease therapy
Agustina Zorgniotti, Aditi Sharma, Sacnicte Ramirez-Rios, Chadni Sanyal, Martina Aleman, Yanina Ditamo, Marie-Jo Moutin, C. Gastón Bisig, Leticia Peris
J npj Parkinsons Dis. 11, 298 (2025). doi.org/10.1038/s41531-025-01143-4 - Event-related potential alterations in bipolar disorder subtypes and mood states: Insights from an emotional visual task
Ronen Sosnik, Antoine Bertrand, Muli Linder, Mircea Polosan
J Affect Disord. 2025 Dec 15;391:119970. doi: 10.1016/j.jad.2025.119970. Epub 2025 Jul 23. PMID: 40712679. - Event-related potential alterations in bipolar disorder subtypes and mood states: Insights from an emotional visual task
Ronen Sosnik, Antoine Bertrand, Muli Linder, Mircea Polosan
J Affect Disord. 2025 Dec 15;391:119970. doi: 10.1016/j.jad.2025.119970. Epub 2025 Jul 23. PMID: 40712679. - Cortical evidence accumulation for visual perception occurs irrespective of reports
François Stockart, Ramla Msheik, Alexis Robin, Lenka Jurkovičová, Dorian Goueytes, Martin Rouy, Radek Mareček, Dominique Hoffmann, Liad Mudrik, Robert Roman, Milan Brázdil, Lorella Minotti, Philippe Kahane, Michael Pereira*, Nathan Faivre*.
Nat Commun. 2025 Sep 26;16(1):8458. doi: 10.1038/s41467-025-63255-y.* contribution égale. - Magnetic resonance-guided ultrasound thalamotomy for essential tremor: a review.
De Schlichting E, Meng Y, Huang Y, Jones RM, Hynynen K, Hamani C, Abrahao A, Davidson B, Lipsman N.
Expert Rev Med Devices. 2025 Jul 11:1-9. doi: 10.1080/17434440.2025.2530765. - Characterizing early auditory deficits in schizophrenia using drift-diffusion modeling.
Dondé C, Pereira M, Nalborczyk L, Roux P, Faivre N, Brunelin J.
Schizophr Res. 2025 Jul 29;284:23-31. doi: 10.1016/j.schres.2025.07.024. Online ahead of print. PMID: 40737765 - Impaired effort allocation in schizophrenia
Blouzard E, Cignetti F, Meyniel F, Pouchon A, Polosan M, Bastin J, Dondé C.
Schizophr Res Cogn. 2025 Jul 15;42:100378. doi: 10.1016/j.scog.2025.100378. eCollection 2025 Dec. PMID: 40697646 Free PMC article. - Astrocytes functionally integrate multiple synapses via specialized leaflet domains.
Lucas Benoit, Ines Hristovska, Nicolas Liaudet, Pierre-Henri Jouneau, Arnold Fertin, Roberta de Ceglia, David Litvin, Maria Amalia Di Castro, Milica Jevtic, Ioannis Zalachoras, Toko Kikuchi, Ludovic Telley, Matteo Bergami, Yves Usson, Chihiro Hisatsune, Katsuhiko Mikoshiba, Karin Pernet-Gallay, Andrea Volterra
Cell, published online September 24, 2025 DOI 10.1016/j.cell.2025.08.036 - Comorbidities in the mouse model of temporal lobe epilepsy induced by intrahippocampal kainate.
Samalens L, Beets C, Courivaud C, Kahane P, Depaulis A.
Epilepsia. 2025 Jul 17. doi: 10.1111/epi.18553. Online ahead of print. - Subcortical correlates of consciousness with human single neuron recordings
Michael Pereira, Nathan Faivre, Fosco Bernasconi, Nicholas Brandmeir , Jacob E Suffridge, Kaylee Tran, Shuo Wang , Victor Finomore, Peter Konrad , Ali Rezai, Olaf Blanke
Elife. 2025 May 22:13:RP95272. doi: 10.7554/eLife.95272. - The Mn-motif protein MAP6d1 assembles ciliary doublet microtubules.
Dharshini Gopal, Juliette Wu, Julie Delaroche, Christophe Bosc, Manon De Andrade, Eric Denarier, Gregory Effantin, Annie Andrieux, Sylvie Gory-Fauré, Laurence Serre & Isabelle Arnal
Nature Communications, 2025, 16 (1), pp.6210. (10.1038/s41467-025-61679-0) - Relaxometry and contrast-free cerebral microvascular quantification using balanced steady-state free precession MR fingerprinting.
Coudert T, Delphin A, Barrier A, Legris L, Warnking JM, Lamalle L, Doneva M, Lemasson B, Barbier EL, Christen T.
Magn Reson Med. 2025 Jul;94(1):302-316. doi: 10.1002/mrm.30434. Epub 2025 Jan 17.