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Team "Brain, Behavior and Neuromodulation"


Director : Julien BASTIN

Characterization of large functional brain networks involved in pharmaco-resistant psychiatric and neurological disorders using experimental, clinical and modeling approaches.


Cognition, movement disorders, psychiatry, epilepsy, behaviour, functional neurosurgery, neuroanatomy, electrophysiology, neuroimaging, system modeling, deep brain stimulation, transcranial magnetic stimulation, vagus nerve stimulation, EEG.

Research topics

The main focus of our team is to understand the common pathophysiological mechanisms between different psychiatric and neurological diseases. For example, they are all characterized by large neuronal network dysfunction, especially within various loops linking cortical to subcortical structures. This may then explain the complexity of the clinical symptoms observed in those diseases due to its impact on multiple cognitive, motor and emotional dimensions.

In order to characterize the functional and neuroanatomical organization of those large scale networks, establish new brain stimulation strategies and better understand their mechanisms, our team currently develops new research project combining complementary fundamental and clinical approaches:

  • Deep brain stimulation and sub-cortical networks: characterize common subcortical regions (subthalamic nucleus, anterior thalamic nucleus, locomotor mesencephalic areas) involved in various psychiatric and neurological pathologies (movement disorders, epilepsy, depression, obsessive compulsive disorders);
  • Cortical and peripheral stimulation: mapping of neuronal circuits using anatomical (tractography) and functional (excitability) based on clinical recordings from epileptic, psychiatric and Crohn patients.


Techniques used :

  • Ex vivo imaging: immunohistochemistry, neuronal track tracing
  • In vivo neurophysiology: single and multiunit recordings, intracortical and epidural field potentials, electroencephalography (EEG), stereo-electroencephalography (SEEG), magnetoencephalography (MEG), infra-red spectroscopy (NIRS).
  • Neuroimaging: structural and functional MRI, positron emission tomography (PET), CT scan.
  • Behavioural studies: cognitive neurosciences, behavioural and clinical phenotype characterisations.
  • Neurostimulation: deep brain stimulation, direct cortical stimulation, vagus nerve stimulation, transcranial magnetic stimulation (TMS).
  • Data processing: modeling, signal and image processing.


Partners :  

Revealing a novel nociceptive network that links the subthalamic nucleus to pain processing
Pautrat A, Rolland M, Barthelemy M, Baunez C, Sinniger V, Piallat B, Savasta M, Overton PG, David O, Coizet V (2018)
eLife 7:e36607

Deep brain stimulation of the subthalamic nucleus in obsessive-compulsives disorders: long-term follow-up of an open, prospective, observational cohort
Chabardes S, Krack P, Piallat B, Bougerol T, Seigneuret E, Yelnik J, Fernandez Vidal S, David O, Mallet L, Benabid AL, Polosan M. (2020)
J Neurol Neurosurg Psychiatry. Dec;91(12):1349-1356

Mapping the Insula with Stereo‐Electroencephalography: The Emergence of Semiology in Insula Lobe Seizures
Singh R, Principe A, Tadel F, Hoffmann D, Chabardes S, Minotti L, David O, Kahane P. 2020
Annals of Neurology. 88:477–488

Anatomical dissociation of intracerebral signals for reward and punishment prediction errors in humans
Gueguen MCM, Lopez-Persem A, Billeke P, Lachaux J-P, Rheims S, Kahane P, Minotti L, David O, Pessiglione M, Bastin J. (2021)
Nature Communications. 12:3344

Intracerebral mechanisms explaining the impact of incidental feedback on mood state and risky choice
Cecchi R, Vinckier F, Hammer J, Marusic P, Nica A, Rheims S, Trebuchon A, Barbeau E J, Denuelle M, Maillard L, Minotti L, Kahane P, Pessiglione M, Bastin J (2022)
eLife 11:e72440

  •     Clarissa BARATIN
  •     Nathan BARBE
  •     Magali BARTOLOMUCCI
  •     Julien BASTIN
  •     Cécile BATANDIER
  •     Elodie BLOUZARD
  •     Bruno BONAZ
  •     Thierry BOUGEROL
  •     Stephan CHABARDES
  •     Blandine CHANTELOUP-FORÊT
  •     Fabien CIGNETTI
  •     Véronique COIZET
  •     Childéric DEZIER
  •     Clément DONDE
  •     Isabelle GUILLEMAIN
  •     Marjorie HERNANDEZ
  •     Mario HERVAULT
  •     Jessy HUGUES DIT CILES
  •     Philippe KAHANE
  •     Audrey KIST
  •     Lorella MINOTTI
  •     Kevin PAUL
  •     Michael PEREIRA
  •     Brigitte PIALLAT
  •     Mircea POLOSAN
  •     Arnaud POUCHON
  •     Ines RACHIDI
  •     Alexis ROBIN
  •     Mathilde ROUX
  •     Rémi SOUTRENON


News of the team (in french)

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