23 January 2017

In the developing cortex, projection neurons undergo multipolar-bipolar transition, radial-directed migration and differentiation. The contribution of these developmental steps to the structure of the adult cortex is not completely understood. Here, we report that huntingtin (HTT), the protein mutated in Huntington’s disease, is enriched in polarizing projection neurons. The depletion of HTT in postmitotic projection neurons leads to the mislocalization of layer-specific neuronal populations in the mouse neocortex.

25 October 2016

Identification of a new mode of energy supply for axonal transport


The whole GIN news

Recent publications


Coarelli G, Diallo A, Thion MS, Rinaldi D, Calvas F, Boukbiza OL, Tataru A, Charles P, Tranchant C, Marelli C, Ewenczyk C, Tchikviladzé M, Monin ML, Carlander B, Anheim M, Brice A, Mochel F, Tezenas du Montcel S, Humbert S, Durr A, (2017) Low cancer prevalence in polyglutamine expansion diseases. Neurology. 2017 Feb 15. pii: 10.1212/WNL.0000000000003725. doi: 10.1212/WNL.0000000000003725. [Epub ahead of print]

Barnat M, Le Friec J, Benstaali C and Humbert S, (2017) Huntingtin-Mediated Multipolar-Bipolar Transition of Newborn Cortical Neurons Is Critical for Their Postnatal Neuronal Morphology. Neuron, Volume 93, Issue 1, p99–114.

Hinckelmann M-V, Virlogeux A, Niehage C, Poujol C, Choquet D, Hoflack B, Zala D & Saudou F (2016). Self-propelling vesicles define glycolysis as the minimal energy machinery for neuronal transport. Nature Communications 7, Article number: 13233.

Pouyatos B, Nemoz C, Chabrol T, Potez M, Bräuer E, Renaud L, Pernet-Gallay K, Estève F, David, O, Kahane P, Laissue JA, Depaulis A, Serduc R (2016). Synchrotron X-ray microtransections: a non invasive approach for epileptic seizures arising from eloquent cortical areas. Nature Publishing Group 6, 27250.

Stamboulian-Platel S, Legendre A, Chabrol T, Platel J-C, Pernot F, Duveau V, Roucard C, Baudry M, Depaulis A (2016). Activation of GABAA receptors controls mesiotemporal lobe epilepsy despite changes in chloride transporters expression: In vivo and in silico approach. Experimental Neurology 284, 11–28.



No english event.

The whole GIN agenda