- Share
- Share on Facebook
- Share on X
- Share on LinkedIn
Thesis defence / Team Benjamin LEMASSON and Thomas CHRISTEN
On May 30, 2024
![PhD defense APlaindoux](/sites/default/files/2024-05/thesis_illu_Plaindoux_0.png)
PhD defense of Alicia Plaindoux
On Thursday May the 30th 2024, Alicia PLAINDOUX will defend his thesis.
This thesis has been directed by Benjamin LEMASSON from the "Functional Neuroimaging and Brain Perfusion" team of the GIN and Florence FAUVELLE and Vasile STUPAR from IRMaGe.
Jury members
- Yannick CREMILLIEUX
- Hélène RATINEY
- Philippe KAHANE
- Angèle VIOLA
- Julien VALETTE
Abstract
For the 30% of patients with drug-resistant epilepsy, mainly with focal epilepsy, surgical resection of the epileptogenic zone (EZ) can be proposed with an average efficiency of 50-80%. Precise identification of the EZ is essential for effective resection.
Despite a wide panel of non-invasive preoperative explorations, intracranial EEG (iEEG) is often necessary. However, poor spatial sampling of individual electrodes and/or poorly guided implantation can result in the resection of an insufficient brain area. Therefore, the development of non-invasive methods to better identify the EZ and guide electrode implantation remains a challenge.
Metabolomics based on nuclear magnetic resonance spectroscopy (MRS) could address this problem in mesiotemporal lobe epilepsy (MTLE), the prototype of surgical epilepsy. In this study, the KA-MTLE mouse model, highly predictive of human MTLE, with a typical EEG profile and hippocampal sclerosis visible on the anatomical MRI, was used. By ex vivo MRS, the metabolic profile of the EZ in this model was determined, and GABA emerged as the most discriminating metabolite with an increase of around 100%. Thus, GABA appears to be a specific biomarker of the ZE in KA-MTLE mice.
In this thesis, a NMR spectroscopic imaging method was developed to map GABA. The results obtained were coupled with multiparametric MRI data to assess the relevance of combining these two methods for the spatial localisation of the EZ. Finally, a preliminary biological study was conducted to try and establish a link between epilepsy and the measured increase in GABA.
Date
On May 30, 2024
Complément date
2pm
Localisation
Complément lieu
GIN - Serge Kampf amphitheater
- Share
- Share on Facebook
- Share on X
- Share on LinkedIn