A study conducted at the Grenoble Institute of Neuroscience shows, in a progressive macaque model of Parkinson’s disease, that activity in the subthalamic nucleus changes before the onset of motivational, cognitive and then motor impairments. These findings could pave the way for deep brain stimulation strategies better tailored to each patient’s symptoms.
In preclinical research on alcohol addiction, rats are often housed alone. A team from the Grenoble Institute of Neurosciences investigated whether they could be housed in pairs without compromising the validity of the experimental model. Their findings reveal a more complex picture than might be expected.
Eq A.Buisson
The kinetochore: an unexpected player in neuronal connectivity
From July 16, 2026 to September 30, 2026
Essential for cell division, kinetochore proteins also play an unexpected role in mature neurons. While a US research team had observed their influence on dendritic spine formation, Leticia Peris’s expertise helped uncover the underlying mechanism: these proteins control microtubule dynamics within neurons.
Eq M.Decressac
Leigh syndrome: Ultrasound-assisted gene therapy, a promising strategy
On March 3, 2026
In a paper published in Brain, the team led by Michael Decressac succeeded in restoring the expression of the NDUFS4 gene in a mouse model of Leigh syndrome using ultrasound-assisted gene therapy. This innovative approach was associated with significant benefits in terms of survival and brain function in the treated animals.
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A study conducted at the Grenoble Institute of Neuroscience shows, in a progressive macaque model of Parkinson’s disease, that activity in the subthalamic nucleus changes before the onset of motivational, cognitive and then motor impairments. These findings could pave the way for deep brain stimulation strategies better tailored to each patient’s symptoms.
In preclinical research on alcohol addiction, rats are often housed alone. A team from the Grenoble Institute of Neurosciences investigated whether they could be housed in pairs without compromising the validity of the experimental model. Their findings reveal a more complex picture than might be expected.
Communiqué, Accolade/Award
Assessing the impact of isolation more accurately to improve laboratory animal welfare
On July 31, 2026
The EDHOSI2HAR project, led by Colin Deransart, a researcher at GIN, has received €30,000 in funding from the France Centre 3R (FC3R) research consortium to study the effects of social isolation in adult rats. In particular, it will assess whether daily handling can help mitigate the potential consequences of isolation on animal welfare.
Latest publications
- Behavioral changes preceded by subthalamic nucleus activity alterations in a progressive macaque model of Parkinson’s disease
Mathilde Bertrand, Stephan Chabardes, Jessy Hugues Dit Ciles, Nicolas De Leiris, Julien Bastin & Brigitte Piallat
npj Parkinsons Dis. (2026). doi.org/10.1038/s41531-026-01498-2 - Impact of paired-housing on a preclinical model of alcohol use disorder
Cécile Gaudart, Mylène Wilt, Fanny Joly, Raphaël Goutaudier, Colin Deransart, Yvan M. Vachez, Sebastien Carnicella
Drug and Alcohol Dependence, Volume 287, 2026. doi.org/10.1016/j.drugalcdep.2026.113289. - Kinetochore proteins control microtubule dynamics in postmitotic neurons to regulate the formation of dendritic spines
Zhao G, Sharma A, Tang J, Aleman M, Liang X, Miner L, Qi J, Xiang W, Tian F, Goldberg Y, He Z, Shen K, Peris L, L Schwarz T.
Proc Natl Acad Sci U S A. 2026 May 5;123(18):e2520684123. doi: 10.1073/pnas.2520684123. - Ultrasound-assisted gene therapy mitigates Leigh syndrome pathology
Mathilde Faideau, Romain Clément, Sébastien Rigollet, Giorgia Benegiamo, Cassandra Cresson, Béatrice Blot, Robin Reynaud-Dulaurier, Sara Yjjou, Fanny Aprahamian, Sylvère Durand, Anthony Delalande, Emmanuel L Barbier, Vasile Stupar, Johan Auwerx, Michael Decressac
Brain,2026 Jan 23. doi: 10.1093/brain/awag026. - A frugal Spiking Neural Network for unsupervised multivariate temporal pattern classification and multichannel spike sorting
Sai Deepesh Pokala, Marie Bernert, Takuya Nanami, Takashi Kohno, Timothée Lévi & Blaise Yvert
Nature Communications vol. 16, Article number: 9218 (2025) - Synchrotron-generated microbeams as a radiosurgical alternative for drug-resistant epilepsies: Proof of concept in a mouse model of mesiotemporal lobe epilepsy
Loan Samalens, Camille Beets, Clothilde Courivaud, Sarvenaz Keshmiri, Jean-François Adam, Paolo Pellicioli, Emmanuel Luc Barbier, Raphaël Serduc, Antoine Depaulis
Epilepsia. 2025 Dec 23. doi: 10.1002/epi.70063. Online ahead of print - L-Dopa-modified microtubules lead to synapse instability in cultured neurons: possible implications in Parkinson’s disease therapy
Agustina Zorgniotti, Aditi Sharma, Sacnicte Ramirez-Rios, Chadni Sanyal, Martina Aleman, Yanina Ditamo, Marie-Jo Moutin, C. Gastón Bisig, Leticia Peris
J npj Parkinsons Dis. 11, 298 (2025). doi.org/10.1038/s41531-025-01143-4 - Event-related potential alterations in bipolar disorder subtypes and mood states: Insights from an emotional visual task
Ronen Sosnik, Antoine Bertrand, Muli Linder, Mircea Polosan
J Affect Disord. 2025 Dec 15;391:119970. doi: 10.1016/j.jad.2025.119970. Epub 2025 Jul 23. PMID: 40712679. - Cortical evidence accumulation for visual perception occurs irrespective of reports
François Stockart, Ramla Msheik, Alexis Robin, Lenka Jurkovičová, Dorian Goueytes, Martin Rouy, Radek Mareček, Dominique Hoffmann, Liad Mudrik, Robert Roman, Milan Brázdil, Lorella Minotti, Philippe Kahane, Michael Pereira*, Nathan Faivre*.
Nat Commun. 2025 Sep 26;16(1):8458. doi: 10.1038/s41467-025-63255-y.* contribution égale. - Magnetic resonance-guided ultrasound thalamotomy for essential tremor: a review.
De Schlichting E, Meng Y, Huang Y, Jones RM, Hynynen K, Hamani C, Abrahao A, Davidson B, Lipsman N.
Expert Rev Med Devices. 2025 Jul 11:1-9. doi: 10.1080/17434440.2025.2530765. - Characterizing early auditory deficits in schizophrenia using drift-diffusion modeling.
Dondé C, Pereira M, Nalborczyk L, Roux P, Faivre N, Brunelin J.
Schizophr Res. 2025 Jul 29;284:23-31. doi: 10.1016/j.schres.2025.07.024. - Impaired effort allocation in schizophrenia
Blouzard E, Cignetti F, Meyniel F, Pouchon A, Polosan M, Bastin J, Dondé C.
Schizophr Res Cogn. 2025 Jul 15;42:100378. doi: 10.1016/j.scog.2025.100378. eCollection 2025 Dec. PMID: 40697646 Free PMC article. - Astrocytes functionally integrate multiple synapses via specialized leaflet domains.
Lucas Benoit, Ines Hristovska, Nicolas Liaudet, Pierre-Henri Jouneau, Arnold Fertin, Roberta de Ceglia, David Litvin, Maria Amalia Di Castro, Milica Jevtic, Ioannis Zalachoras, Toko Kikuchi, Ludovic Telley, Matteo Bergami, Yves Usson, Chihiro Hisatsune, Katsuhiko Mikoshiba, Karin Pernet-Gallay, Andrea Volterra
Cell, published online September 24, 2025 DOI 10.1016/j.cell.2025.08.036 - Comorbidities in the mouse model of temporal lobe epilepsy induced by intrahippocampal kainate.
Samalens L, Beets C, Courivaud C, Kahane P, Depaulis A.
Epilepsia. 2025 Jul 17. doi: 10.1111/epi.18553. Online ahead of print. - Subcortical correlates of consciousness with human single neuron recordings
Michael Pereira, Nathan Faivre, Fosco Bernasconi, Nicholas Brandmeir , Jacob E Suffridge, Kaylee Tran, Shuo Wang , Victor Finomore, Peter Konrad , Ali Rezai, Olaf Blanke
Elife. 2025 May 22:13:RP95272. doi: 10.7554/eLife.95272. - The Mn-motif protein MAP6d1 assembles ciliary doublet microtubules.
Dharshini Gopal, Juliette Wu, Julie Delaroche, Christophe Bosc, Manon De Andrade, Eric Denarier, Gregory Effantin, Annie Andrieux, Sylvie Gory-Fauré, Laurence Serre & Isabelle Arnal
Nature Communications, 2025, 16 (1), pp.6210. (10.1038/s41467-025-61679-0) - Relaxometry and contrast-free cerebral microvascular quantification using balanced steady-state free precession MR fingerprinting.
Coudert T, Delphin A, Barrier A, Legris L, Warnking JM, Lamalle L, Doneva M, Lemasson B, Barbier EL, Christen T.
Magn Reson Med. 2025 Jul;94(1):302-316. doi: 10.1002/mrm.30434. Epub 2025 Jan 17.