VIRGINIE MELLET STOPPIN

Teaching topics:

• Cell biology: CPP INPG (courses & TD), L2 and L3 UGA (TD & TP)
• Biochemistry: L2 UGA (TD & TP)
• Animal physiology: CPP INPG (lectures)
• Physical properties of the cell: M1 SMB (course)
• Soft Matter and Biophysics: M1 (TD & TP)

I was initially trained as an engineer in agronomy (1990, Rennes, France) and as a plant biologist at the University of Strasbourg where I obtained a PhD in 1994. My research work, conducted in the group of Pr AM Lambert (Institute of Plant Molecular Biology, Strasbourg, France), has identified the nuclear surface as the main plant microtubule organizing center, equivalent of the centrosome in animal cells. After a postdoc at Johns Hopkins School of Medicine (group of D. Murphy, Baltimore, USA), I obtained a tenure position as an associated professor at the University of Strasbourg (CNU 65). I conducted research at the Institute for Plant Molecular Biology (IBMP) on the identification of proteins involved in plant microtubule nucleation. I then moved to the University of Grenoble (CNU 64) where I joined the group of M. Vantard at the CEA. In this period, I worked on the regulators of microtubules and developed in vitro approaches using biomimetic assays and TIRF microscopy. In 2014, I joined the group of I. Arnal at Grenoble Institute of Neurosciences where I work on two main projects: 1- the role of GTP hydrolysis in the regulation of microtubule dynamics, 2 - the role of tau on the regulation of microtubule and actin networks.

Since January 2014 Associate Professor - Grenoble Alpes University & Grenoble Institute of Neuroscience - Neuronal Cytoskeleton Dynamics and Structure Team - Leaders I. Arnal & A. Andrieux
Projects: 1/ Regulation of microtubule and actin cytoskeletons by Tau protein
                2/ Role of Tau in the dynamics of focal adhesions
                3/ Fundamental mechanisms of microtubule stability

1999-2013 Associate Professor - Grenoble Alpes University & Laboratoire de Physiologie Cellulaire et Végétale (LPCV) - Microtubule dynamics team - M. Vantard and L. Blanchoin 
Projects: 1/ Molecular and functional characterization of A. thaliana katanin involved in microtubule fragmentation publications 
               2/ Characterization of microtubule-associated proteins of the MAP65 family publications 

1995-1999 Associate Professor - University of Strasbourg & Institute of Plant Molecular Biology (IBMP) - Team Pr AM Lambert
Project: Identification of proteins involved in microtubule nucleation in higher plants publications 

1994-1995 Post-doctoral researcher — Johns Hopkins University School of Medicine, Baltimore, USA - Team D. Murphy
Project: Study of the segregation of MAP2 and Tau microtubule-associated proteins in neurons and their role in neuronal differentiation

1991-1994 PhD in Biology — Institute of Plant Molecular Biology (IBMP) - Dir. Pr AM Lambert
Project: Identification and functional characterization of microtubule organizing centers in higher plants publications 

Recent publications
Stable GDP-tubulin islands rescue dynamic microtubules. Bagdadi et al. J Cell Biol. 2024 doi: 10.1083/jcb.202307074.

VASH1-SVBP and VASH2-SVBP generate different detyrosination profiles on microtubules. Ramirez-Rios S et al. J Cell Biol. 2023 doi: 10.1083/jcb.202205096

Studying Tau-Microtubule Interaction Using Single-Molecule TIRF Microscopy. Stoppin-Mellet V et al. Methods Mol Biol. 2020 doi: 10.1007/978-1-0716-0219-5_6.

The complete list of my publications can be found on PubMed or ORCID 0000-0002-1958-1306