Development of a therapeutic approach by genome editing for RyR1-related disorders: from in vitro study to in vivo application

On Tuesday September 30th 2025, Margaux MELKA will defend his thesis "Development of a therapeutic approach by genome editing for RyR1-related disorders: from in vitro study to in vivo application".

This thesis has been directed by Isabelle Marty and John Rendu of the "Cellular Myology and Pathologies" team of the GIN.

Jury composition :

- Caroline LE GUIN, Inserm, Délégation Grand-Ouest, Rapporteur 
- Emiliano RICCI, Inserm, Délégation Auvergne Rhône-Alpes, Rapporteur 
- Bruno ALLAR, Université Lyon 1, Examinateur 
- Walid RACHIDI, Université Grenoble Alpes, Examinateur 
- John RENDU, CHU, Université Grenoble Alpes, Co-directeur de thèse 
- Isabelle Marty, Inserm, Délégation Auvergne Rhône-Alpes, Directrice de thèse