A GIN article in the Journal of Cell Biology's twelve most outstanding publications of 2024

From the 400 scientific articles published in the Journal of Cell Biology in 2024, the editorial board selected the twelve that “most captivated readers” during the year. This selection of outstanding articles reports significant advances in the understanding of the living world from a cellular point of view. It also illustrates the variety and exceptional quality of the research published by this scientific journal, founded in 1955.

The article “Stable GDP-tubulin islands rescue dynamic microtubules” from GIN's Team "Neurocytoskeleton Dynamics and Structure", co-authored by Nassiba Bagdadi, Annie Andrieux, Virginie Stoppin-Mellet and Isabelle Arnal, among others, is featured in this selection.

The team shows that GDP-tubulin, previously considered inactive in microtubule assembly, is in fact capable of forming microtubules with unique properties: remarkably stable, they do not spontaneously disassemble.

These stable microtubules could play a crucial role in differentiated cells such as neurons, where increased stability of the microtubule network is essential for their proper functioning. Another example is the regeneration of axons after injury, which requires an appropriate balance between dynamic and stable microtubule populations.

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Reference: 
Nassiba Bagdadi, Juliette Wu, Julie Delaroche, Laurence Serre, Christian Delphin, Manon De Andrade, Marion Carcel, Homaira Nawabi, Benoît Pinson, Claire Vérin, Yohann Couté, Sylvie Gory-Fauré, Annie Andrieux*, Virginie Stoppin-Mellet*# & Isabelle Arnal*# 
GDP-tubulin polymerizes into stable microtubules. J Cell Biol,  223 (8): e202307074. https://doi.org/10.1083/jcb.202307074 
(*, co-correponding authors; #, co-last authors).