ANTOINE DEPAULIS
Directeur de recherche (INSERM)
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Coordonnées
Bâtiment : Grenoble Institut des Neurosciences
Bureau : 1/074
Antoine.Depaulis@univ-grenoble-alpes.fr
Site web :
Réseaux sociaux :
Thèmes de recherche
I have been working on the neurobiology of Epilepsy for 43 years and have a solid experience in multidisciplinary research management and coordination as the group leader of a translational team from 1992 to 2020, the deputy-director of the Grenoble Institute for Neuroscience (2010-2013), the PI of several French and European collaborative programs and the founder and coordinator of national and European networks. My personal goal is a better understanding of neural circuits involved in epilepsy and the development of innovative therapies based on this knowledge.
Disciplines scientifiques
Neuroscience, Epileptology, Neurobiology, Electrophysiology, Animal models
Curriculum vitae
I was trained as a Biologist at the University of Bordeaux and then Strasbourg where I obtained a PhD in Neuroscience in 1983. After a postdoc at Pr John Liebeskind's laboratory at UCLA (Los Angeles), I obtained a tenured position at Inserm (chargé de recherche) in 1986 in the laboratory of Pr Pierre Karli to work in the group of Dr Marguerite Vergnes. I obtained a second PhD in Pharmacology in 1990 and then the habilitation to supervise research (HDR) in 1994. I was promoted Junior Director of Research in 1999 and created my own team to work on neural circuits initiating or controlling epileptic seizures using animal models, in the Inserm Unit directed by Pr Christian Marescaux.
In 2003, I moved to Grenoble to set up a new translational research group with Pr Philippe Kahane to work on epilepsy at the Grenoble Institute for Neuroscience directed by Pr Claude Feuerstein. I was a deputy director of this Institute from 2010 to 2013 and was promoted Senior Director of Research in 2015. In 2021, I joined the team of Emmanuel Barbier, since I will retire in 2025.
During my career, I characterized two animal models of epilepsy : the Genetic Absence Epilepsy Rat from Strasbourg (GAERS) and the mouse model of Mesio-temporal lobe epilepsy induced by intra-hippocampal injection of kainate (KA-MTLE mouse).
Publications
Key Publications - for complete list of publications see https://orcid.org/0000-0001-6543-6700
- David O, Guillemain I, Saillet S, Reyt S, Deransart C, Segebarth C, Depaulis A. Identifying Neural Drivers with Functional MRI: An Electrophysiological Validation. Plos Biol. 2008, 6(12):e315–2697.
- Heinrich C, Lähteinen S, Suzuki F, Laharie AM, Huber S, Häussler U, Haas C, Larmet Y, Castren E, Depaulis A. Increase in BDNF-mediated TrkB signaling promotes epileptogenesis in a mouse model of mesial temporal lobe epilepsy. Neurobiol Dis. 2011, 42(1):35–47.
- Depaulis A, David O, Charpier S. The genetic absence epilepsy rat from Strasbourg as a model to decipher the neuronal and network mechanisms of generalized idiopathic epilepsies. J Neurosci Meth. 2016, 260:159–74.
- Pouyatos B, Nemoz C, Chabrol T, Potez M, Bräuer E, Renaud L, Pernet-Galay K, Estève F, David O, Kahane P, Laissue JA, Depaulis A, Serduc R. Synchrotron X-ray microtransections: a non invasive approach for epileptic seizures arising from eloquent cortical areas. Sci Reports. 2016, 6:27250.
- Jarre G, Altwegg-Boussac T, Williams MS, Studer F, Chipaux M, David O, Charpier S, Depaulis A, Mahon S, Guillemain I. Building Up Absence Seizures in the Somatosensory Cortex: From Network to Cellular Epileptogenic Processes. Cereb Cortex 2017, 27:4607–4623.
- Studer F, Laghouati E, Jarre G, David O, Pouyatos B, Depaulis A Sensory coding is impaired in rat absence epilepsy. J Physiol 597:951–966.
- Studer F, Jarre G, Pouyatos B, Nemoz C, Brauer-Krisch E, Muzelle C, Serduc R, Heinrich C, Depaulis A Aberrant neuronal connectivity in the cortex drives generation of seizures in rat absence epilepsy. Brain. 2022 Jun 30;145(6):1978-1991.
- Plutino S, Laghouati E, Jarre G, Depaulis A, Guillemain I, Bureau I. Barrel cortex development lacks a key stage of hyperconnectivity from deep to superficial layers in a rat model of Absence Epilepsy. Prog Neurobiol. 2024 Mar;234:102564
Informations complémentaires
EXPERIENCE OF RESEARCH MANAGEMENT
1995-2020 Leader of a translational research team including biologists and clinicians in Strasbourg, then Grenoble (since 2003).
1998-2003 Founder and General Secretary of Neurex a trinational network of 1,000 neuroscientists in the upper Rhine Valley (France, Germany, Switzerland), Strasbourg.
2002-2007 Founder and President of Club EpilepsieS, a french network of clinicians and scientists conducting research in Epileptology, France.
2004-2008 Founder and coordinator of GRACE, a working group on communication at the Grenoble Institute of Neuroscience.
2006-2009 Coordinator (PI) of a European consortium (STREP : Valapodyn) including 6 partners.
2010 - 2013 Deputy Director of the Grenoble Institute of Neuroscience, in charge of communication.
Since 2005 Founder, advisor and Shareholder of SynapCell (Grenoble), a biotech company.
2012 - 2016 Coordinator of a workpackage in a FP7 European consortium (collaborative programme : Neurinox).
2014 - 2017 Coordinator of a working group in a COST European network (SYRA 3)
2014 - 2020 Member of the steering committee of a University Hospital Federation (NeuroPsyNov) in Grenoble.
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