Tubulin re-tyrosination is perturbed in Alzheimer's disease

Peris, Parato, Qu et al. show that the amount of tubulin tyrosine ligase is reduced in Alzheimer’s disease brains and that normal levels of tyrosinated tubulin are required for synaptic integrity, normal cognitive function and resistance to Aβ-induced synaptic damage by promoting microtubule entry into dendritic spines.

Reference:
Tubulin tyrosination regulates synaptic function and is disrupted in Alzheimer’s disease
Leticia Peris, Julie Parato, Xiaoyi Qu, and al.
Brain, Volume 145, Issue 7, July 2022, Pages 2486–2506,