Contenu

x

Moteur de recherche interne

Grenoble Institut des Neurosciences Grenoble Institut des Neurosciences

  • Youtube
  • Linkedin
  • Twitter

Accueil > Recherche > Animation scientifique > Séminaires

Accéder au plan complet du site

Targeting the Ventral Pallidum to Treat Addictive Disorders

le 11 octobre 2018
11h30

Séminaire de Meaghan Creed (University of Maryland School of Medicine, Baltimore, USA)

Addiction is a disorder of behavioral symptoms including sensitization to drug-associated cues, negative affect and compulsive drug seeking. Cocaine-evoked synaptic plasticity in the reward system, particularly the nucleus accumbens (NAc) and its main output structure, the ventral pallidum (VP) drives drug-adaptive behavior. However, how information is integrated downstream of the NAc remains unclear. Here, we identify the ventral pallidum (VP) as a site of convergence of direct and indirect pathways from the NAc. Cocaine potentiated output of D1-MSNs, but weakened output of D2-MSNs, occluding LTP and LTD at these synapses, respectively. Restoring basal transmission at D1-MSN-to-VP synapses abolished locomotor sensitization, whereas restoring transmission at D2-MSN-to-VP synapses normalized motivational deficits. We further identified a non-canonical population of neurons in the VP that specifically constrain reward seeking in the face of aversive consequences, which is a hallmark feature of addiction. Our results support a model by which drug-evoked synaptic plasticity in the VP mediates diverse behavioral symptoms of addiction; targeting the VP with neuromodulation may provide novel therapeutic strategies for addictive disorders.

Meaghan Creed est invitée par Sabrina Boulet.

Infos pratiques

Lieu

Amphi Serge Kampf
Mise à jour le 6 septembre 2018

Membres
Associés renforcés
Associés simples