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Anatomical and Functional Neuroimaging of the Marmoset Brain

le 27 juin 2018
11h30

Séminaire d'Afonso Silva (Laboratory of Functional and Molecular Imaging, NINDS, Bethesda, USA)

The common marmoset (Callithrix jacchus) is a small New World monkey that has gained significant recent interest in neuroscience research, due in great part for its compatibility with gene editing techniques, but also due to its tremendous versatility as an experimental animal model. Neuroimaging modalities, including anatomical (MRI) and functional magnetic resonance imaging (fMRI), complemented by two-photon laser scanning microscopy and electrophysiology, have been at the forefront of unraveling the anatomical and functional organization of the marmoset brain. High resolution anatomical MRI of the marmoset brain can be obtained with remarkable cytoarchitectonic detail. Functional MRI of the marmoset brain has been used to study various sensory systems, including somatosensory, auditory and visual pathways, while resting-state fMRI studies have unraveled functional brain networks that bear great correspondence to those previously described in humans. Two-photon laser scanning microscopy of the marmoset brain has enabled the simultaneous recording of neuronal activity from thousands of neurons with single cell spatial resolution. In this talk, we will review the main results obtained by our group and our colleagues in applying neuroimaging techniques to study the marmoset brain.

References:

  1. Silva AC. Anatomical and functional neuroimaging in awake, behaving marmosets. Dev Neurobiol. 2017 Mar;77(3):373-389.

  2. Papoti D, Yen CC, Hung CC, Ciuchta J, Leopold DA, Silva AC. Design and implementation of embedded 8-channel receive-only arrays for whole-brain MRI and fMRI of conscious awake marmosets. Magn Reson Med. 2017 Jul;78(1):387-398.

  3. Toarmino CR, Yen CC, Papoti D, Bock NA, Leopold DA, Miller CT, Silva AC. Functional Magnetic Resonance Imaging of Auditory Cortical Fields in Awake Marmosets. Neuroimage 2017 Nov 15;162:86-92.

  4. Liu C, Ye FQ, Yen CC, Newman JD, Glen D, Leopold DA, Silva AC. A digital 3D atlas of the marmoset brain based on multi-modal MRI. Neuroimage 2017 Dec 5;169:106-116.

  5. Yen CC, Papoti D, Silva AC. Investigating the spatiotemporal characteristics of the deoxyhemoglobin-related and deoxyhemoglobin-unrelated functional hemodynamic response across cortical layers in awake marmosets. Neuroimage 2018 Jan 1;164:121-130.

  6. Hirano Y, Yen CC, Liu JV, Mackel JB, Merkle H, Nascimento GC, Stefanovic B, Silva AC. Investigation of the BOLD and CBV fMRI responses to somatosensory stimulation in awake marmosets (Callithrix jacchus). NMR Biomed 2018 Mar;31(3). doi: 10.1002/nbm.3864. Epub 2017 Dec 29.

  7. Hung CC, Yen CC, Ciuchta JL, Papoti D, Bock NA, Leopold DA, Silva AC. Functional Mapping of Face-Selective Regions in the Extrastriate Visual Cortex of the Marmoset. J Neurosci. 2015 35(3):1160-72.

  8. Santisakultarm TP, Kersbergen CJ, Bandy DK, Ide DC, Choi SH, Silva AC. Two-photon Imaging of Cerebral Hemodynamics and Neural Activity in Awake and Anesthetized Marmosets. J Neurosci Methods. 2016 Sep 15;271:55-64.

  9. Park JE, Zhang XF, Choi SH, Okahara J, Sasaki E, Silva AC. Generation of transgenic marmosets expressing genetically encoded calcium indicators. Sci Rep. 2016 Oct 11;6:34931. doi: 10.1038/srep34931.


Afonso Silva est invité par Emmanuel Barbier.

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Amphi Serge Kampf
Mise à jour le 6 juin 2018

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