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Understanding neuronal fat accumulation in Parkinson's Disease: Insights from Drosophila

le 7 février 2019

Séminaire de Bertrand Mollereau (Laboratoire de Biologie et de Modélisation de la Cellule, ENS de Lyon)

Increasing evidence suggests that dysregulation of lipid metabolism is associated with neurodegeneration in brain disorders such as Alzheimer’s and Parkinson’s diseases. Lipid storage organelles (lipid droplets, LDs), accumulate in many cell types in response to stress, and it is now clear that LDs function not only as lipid stores but also as dynamic regulators of the stress response. However, whether these LD are always protective or can also be deleterious to the cell is matter of debate. We recently showed that dFatp (Drosophila fatty acid transport protein) is required and sufficient LD formation in retinal pigment cells (RPCs) and that FATP-mediated LD formation in RPCs promotes neuronal homeostasis (Van Den Brink et al. 2018). Furthermore, we used a Drosophila expressing alpha-synuclein as model of Parkinson’s disease (PD) in which we observed a neuronal accumulation of LD in Drosophila. During the seminar, I will discuss the mechanisms leading to LD accumulation and its pathological relevance in neurodegeneration.
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Bertrand Mollereau est invité par Annie Andrieux.

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Amphi Serge Kampf
Mise à jour le 25 janvier 2019

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