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Little fishes make big waves ? the use of zebrafish to model neurological disorders

le 21 octobre 2016
de 11h à 12h

Séminaire de Mélanie Langlois (Université du Luxembourg)

 

Despite the availability of a large and growing number of epilepsy models and screening assays, both in vitro and in vivo, there are still significant challenges in the field of anti-epileptic drug discovery.

Besides the traditional and widely used rodent models, the use of non-mammalian “lower” species has recently emerged and is now of great interest to study some fundamental aspects of epileptogenesis, ictogenesis and disease-modifying processes. The growing attractiveness of simple model organisms such as Danio rerio relies on its low cost, small size and easy transgenesis, allowing high throughput screening of genetic variants that carry induced mutations thought to be involved in human genetic epilepsies. To confirm that the convulsive behavior elicited in larval zebrafish is indeed a result of seizures, confirmation through brain activity recordings is vital. Local field potential recording protocols were developed and optimized to measure epileptiform discharges from zebrafish larval brains. Similar to the locomotor assays, modulation of electrographic seizure patterns by compounds, light and temperature stimuli can be monitored.

Mélanie Langlois est invitée par Rémy Sadoul. Elle donnera également un cours de 9h00 à 11h00 dans le cadre du M2 de Neurosciences.

 


Mise à jour le 22 octobre 2016

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