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Dissecting cell biology using haploid genetics: tubulin detyrosination & beyond

le 10 mars 2022

Séminaire de Thijn Brummelkamp (Netherlands Cancer Institute, Amsterdam)

Whereas accurate maps exist depicting biochemical pathways, equivalent charts do not exist for the genetic wiring of human cells. Our laboratory studies the effect of gene mutations on a battery of quantitative cellular phenotypes. Specifically, we use haploid human cells as a genetic model system and apply insertional mutagenesis to link millions of genomic mutations to cellular phenotypes of interest. This phenotype database can be mined for new players in different cellular processes. In the recent years we have focussed on the identification of missing key enzymatic activities in cell biology. This yielded new enzymes required for establishment of our cytoskeleton, a new pathway in lipid metabolism and new actors in pathways targeted for immunotherapy. Finally, we have identified and characterized the enzymes that detyrosinate tubulin, an abundant and dynamic posttranslational modification of our cytoskeleton linked to human disease.
Thijn Brummelkamp est invité par Marie-Jo Moutin.

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Amphi Kampf
Mise à jour le 28 février 2022

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