Astrocytes-derived L-serine: a key signaling pathway
le 23 novembre 2017 11h30
Séminaire de Gilles Bonvento (MIRCEN, CEA - CNRS, Fontenay-aux-Roses)
Astrocytes predominantly process glucose glycolytically. Aside from ATP production, a major function of glycolysis is to provide precursors such as L-serine, to support macromolecular synthesis. In the brain, L-serine serves as the precursor of D-serine, the principal co-agonist of synaptic N-methyl D-aspartate receptors (NMDAR). I will present experimental data obtained in both human and mice indicating that the biosynthesis of L-serine is of paramount importance in the healthy and diseased (Alzheimer) brain.
Gilles Bonvento est invité par Mireille Albrieux et Alain Buisson.
English
