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Grenoble Institut des Neurosciences Grenoble Institut des Neurosciences

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Understanding the developmental mechanisms regulating the lamination of the cerebral cortex

Objectifs

The project aims to characterize the molecular and cellular mechanisms regulating the brain development during mammalian and human embryogenesis. More specifically, we focus on the development of the cerebral cortex to shed light on the etiology of neurodevelopmental disorders.
 

Résumé

The cerebral cortex is a six-layered brain structure that ensures higher motor, sensory and cognitive functions. Its laminar organization reflects the fine regulation of developmental processes which, if altered, can lead to malformations of cortical development. These malformations are associated with clinical manifestations combining intellectual and/or motor deficits. Therefore, understanding how the cortex develops in utero is a sine qua non condition for deciphering neurodevelopmental disorders and their associated pathophysiological mechanisms. The cortical layers, holding a well-defined number and subtype of excitatory neurons, arise the sequential differentiation of progenitors into neurons that subsequently migrate to reach their final location. Using a combination of multi-scale approaches, we aim to study the developmental mechanisms that regulate the acquisition of neuronal identity and the orderly build-up of cortex with a special focus on crosstalk between the different cell types populating the developing cortex.
 

Méthodes

Murine lines (crossing, genotyping), in utero electroporation, microscopy and videomicroscopy, primary culture (neurons, neuroprogenitors cells and brain slices), histology (embryonic and post-natal brain sections), immunohistochemistry and immunocytochemistry, molecular biology techniques.
 

Références

  • Barnat M, Capizzi M, Aparicio E, Boluda S, Wennagel D, Kacher R, Kassem R, Lenoir S, Agasse F, Braz BY, Liu JP, Ighil J, Tessier A, Zeitlin SO, Duyckaerts C, Dommergues M, Durr A, Humbert S (2020). Huntington's disease alters human neurodevelopment. Science. 369(6505):787-793.
 

Domaines d'expertise requis

Neurobiology, Cortical development, Cellular biology, Cell adhesion and dynamics, Molecular biology
 

Contacts

M. Barnat (CR Inserm)
Email : monia.barnat@univ-grenoble-alpes.fr
Phone : 04 56 52 06 21

Téléchargement(s)

Mise à jour le 8 juillet 2022

Contacts

Pour les stages (master, licence, 3ème), envoyer directement un email au responsable de l'équipe que vous avez identifiée.

Pour une candidature spontanée pour un emploi et uniquement pour cela, envoyez un email à gincomm[at]univ-grenoble-alpes.fr ou utilisez le formulaire de contact.

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