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Grenoble Institut des Neurosciences Grenoble Institut des Neurosciences

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Translational control in Central nervous System regeneration

Objectifs

Our goal is to decipher the central role of protein translation during neurodegeneration/regeneration process in the central nervous system (CNS)

Résumé

A major challenge in Biology is to understand how genes are expressed and regulated in space and time in order to define cell specificity and organism development. This is particularly important in the case of the regeneration of the Central Nervous System (CNS) when neurons depend on specific genes expression to survive and regrow axons. Numerous studies have tried to uncover axon regeneration mechanisms by analyzing neuronal mRNA but ultimately failed to uncover all the programs necessary for regeneration. Using in-vivo approaches combined with molecular biology and biochemistry, we will focus on the role of translation and particularly of the translational complex in the control of expression of critical programs necessary to promote cells survival and axon regeneration.

Méthodes

Molecular biology (cloning, PCR), biochemistry (western-blot, Immunoproecipitation), Cellular biology (Cell line and primary cells culture), Microscopy, Mice handling and surgery

Références

  • H. Nawabi *, S. Belin *, R. Cartoni*, PR. Williams, C. Wang, A. Latremolière, X. Wang, J. Zhu, DG. Taub, X. Fu, B. Yu, X. Gu, CJ. Woolf, JS. Liu, CV. Gabel, JA. Steen, Z. He. Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Neuron 2015 Nov 18;88(4):704-19
  • S. Belin*, H. Nawabi*, C. Wang, S. Tang, P. Warren, A. Latremoliere, H. Schorle, C. Uncu, C.J. Woolf, Z. He, and J. Steen. Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics. Neuron 2015 May 20;86(4):1000-14.)
  • p53 acts as a safeguard of translational control by regulating fibrillarin and rRNA methylation in cancer. Marcel* V, Ghayad* SE, Belin* S, Therizols G, Morel AP, Solano-Gonzàlez E, Vendrell JA, Hacot S, Mertani HC, Albaret MA, Bourdon JC, Jordan L, Thompson A, Tafer Y, Cong R, Bouvet P, Saurin JC, Catez F, Prats AC, Puisieux A, Diaz JJ. *equal contribution Cancer Cell. 2013

Contacts

Stéphane Belin, CR1 Inserm
Email : stephane.belin@inserm.fr

Mise à jour le 23 mai 2017

Contacts

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