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Grenoble Institut des Neurosciences Grenoble Institut des Neurosciences

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SCN innervation during development and upon nerve injury

Objectifs

Our lab seeks to rebuild neuronal circuits after nerve injury. We are interested in axon regeneration mechanisms using the mouse optic nerve as a model. Our project uses in vivo and in vitro systems to decipher processes controlling axonal growth.

Résumé

Unlike the peripheral nervous system, neurons from the central nervous system (brain, spinal cord) are not able to regrow axons after injury. Therefore, any lesion to the CNS leads to permanent motor and/or cognitive impairment. To this day, no treatment is available to overcome CNS injuries. It is now well established that modulating neurons themselves promotes axonal growth. The challenge now is to rebuild functional circuits. To do so, the first step is to connect the correct targets. Retina ganglion cells are the only neurons from the retina that project their axons to form the optic nerve, that belongs to the CNS. The suprachiasmatic nucleus (SCN) is one of the brain targets of those axons. SCN is the master regulator of circadian rhythms. Our lab uncovered a specific expression of repulsive guidance molecule within the SCN. Our aim now it the study the developmental regulation its expression and SCN innervation during development and after injury in adult mouse.

Méthodes

Mouse eye surgery, neuronal tissues culture, molecular biology, imaging, immunohistochemistry.

Références

  • Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Nawabi H, Belin S, Cartoni R, Williams PR, Wang C, Latremolière A, Wang X, Zhu J, Taub DG, Fu X, Yu B, Gu X, Woolf CJ, Liu JS, Gabel CV, Steen JA, He Z. Neuron. 2015 Nov 18
  • Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics. Belin S, Nawabi H, Wang C, Tang S, Latremoliere A, Warren P, Schorle H, Uncu C, Woolf CJ, He Z, Steen JA. Neuron. 2015 May 20

Domaines d'expertise requis

Mouse handling; neurobiology; molecular biology, cellular biology; imaging

Contacts

Homaira NAWABI, Inserm Researcher
Email : homaira.nawabi@univ-grenoble-alpes.fr

Mise à jour le 31 mai 2018

Contacts

Pour une candidature spontanée, envoyez un email à gincomm[at]univ-grenoble-alpes.fr ou utilisez le formulaire de contact.

Pour les stages de licence et de 3ème, voir les modalités de demande spécifiques sur les pages correspondantes. 

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