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Role of ribosome and translation in central nervous system regeneration


The objectives of the project is to define how the translation and more particularly the ribosome impact the capabilities of CNS neurons to survive and/ or regenerate after an injury or during neurodegenerative diseases.


A major challenge in Biology is to understand how genes are expressed and regulated in space and time in order to ensure cell specificity and development. Genetic expression is defined by the flow DNA-RNA-Protein. Tremendous amount of work has focused on the first step of this flow, in contrast, the last step consisting of mRNA translation into proteins is still poorly addressed. Growing body of evidence suggest that translation control and ribosome are critical for cellular life. These observations reinforce a paradigm shift: from a passive housekeeping ribosome to a direct translational regulator. We want to verify this hypothesis in the context of Central Nervous System CNS regeneration and neuroprotection in order to define new therapeutic strategies after CNS injury and neurodegenerative disease.


To develop this project, we will use: mouse model of CNS injury, biochemistry (western blot, immunoprecipitation), immunofluorescence and proteomics approach.


  • Evidence for rRNA 2'-O-methylation plasticity: Control of intrinsic translational capabilities of human ribosomes. Erales J, Marchand V, Panthu B, Gillot S, BELIN STEPHANE, Ghayad SE, Garcia M, Laforêts F, Marcel V, Baudin-Baillieu A, Bertin P, Couté Y, Adrait A, Meyer M, Therizols G, Yusupov M, Namy O, Ohlmann T, Motorin Y, Catez F, Diaz JJ.Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12934-12939. doi: 10.1073/pnas.1707674114. Epub 2017 Nov 20.PMID:29158377
  • Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics. BELIN STEPHANE*, Nawabi H*, Wang C, Tang S, Latremoliere A, Warren P, Schorle H, Uncu C, Woolf CJ, He Z, Steen JA.Neuron. 2015 May 20;86(4):1000-1014. doi: 10.1016/j.neuron.2015.03.060. Epub 2015 Apr 30.PMID:25937169
  • Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. Nawabi H*, BELIN STEPHANE*, Cartoni R, Williams PR, Wang C, Latremolière A, Wang X, Zhu J, Taub DG, Fu X, Yu B, Gu X, Woolf CJ, Liu JS, Gabel CV, Steen JA, He Z. Neuron. 2015 Nov 18;88(4):704-19. doi: 10.1016/j.neuron.2015.10.005. Epub 2015 Oct 29.PMID:26526391

Domaines d'expertise requis

Neurobiology, translation, neuroprotection, axon growth


Dr Stéphane Belin, CRCN Inserm
Email :
Tél: 0756520544

Mise à jour le 6 juin 2019


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