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Grenoble Institut des Neurosciences

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Promoting Central Nervous System regeneration in adult

Objectifs

Our lab seeks to understand mecanisms linked to axon regeneration. Our project uses in vivo and in vitro systems to decipher processes controlling neuroprotection and axonal growth in adult in order to rebuild circuit after traumatic or chronic injury of the central nervous system.

Résumé

Unlike the peripheral nervous system, neurons from the central nervous system (brain, spinal cord) are not able to regrow axons after injury. Therefore, any lesion to the CNS leads to permanent motor and/or cognitive impairment. To this day, no treatment is available to overcome CNS injuries. It is now well established that modulating neurons themselves promotes axonal growth. The challenge now is to identify neuronal targets and molecular pathways that are required for axon regeneration. Our lab is focus on the analysis of the injury signal in order to define new way to promote axon regeneration. We are using a combination of in-vitro, in-vivo assay, molecular biology and biochemistry to characterized new cellular pathway implicated in neuroprotection and axonal growth in order to develop new therapeutic strategies.

Méthodes

Methods developed in the team are: in-vivo model of central and peripheral nervous system injury, westernblot analysis, immunofluorescence. Biochemistry technics link to the analysis of ribosome and ribosomal proteins.

Références

Axon guidance modalities in CNS regeneration revealed by quantitative proteomic analysis Noemie Vilallongue, Julia Schaeffer, Anne-Marie Hesse, Céline Delpech, Antoine Paccard, Yohan Couté, Stephane Belin*, Homaira Nawabi*. BioRxiv doi: https://doi.org/10.1101/2021.03.26.437129 *co-corresponding (Nature Communication, under review)

Adult Mouse Retina Explants: From ex vivo to in vivo Model of Central Nervous System Injuries. Schaeffer J, Delpech C, Albert F, Belin S*, Nawabi H* .Front Mol Neurosci. 2020 Nov 25;13:599948. doi: 10.3389/fnmol.2020.599948. eCollection 2020.PMID: 33324161 *co-corresponding

Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics. Belin* S, Nawabi* H, Wang C, Tang S, Latremoliere A, Warren P, Schorle H, Uncu C, Woolf CJ, He Z, Steen JA. *equal contribution Neuron. 2015 May 20;86(4):1000-14. doi: 10.1016/j.neuron.2015.03.060. Epub 2015 Apr 30.

Domaines d'expertise requis

Neurology, translation, regeneration, neuroprotection

Contacts

S. Belin (CR Inserm)
Email : stephane.belin@inserm.fr
Phone : 076888155

Téléchargement(s)

GIN_offre-stage-M2_2022-2023_SBelin_20220707.pdf (PDF, 137627 Ko)

Mise à jour le 8 juillet 2022

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