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Grenoble Institut des Neurosciences Grenoble Institut des Neurosciences

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Palmitoylation as a new therapeutic approach for curing Huntington disease


The objectives of the project are to decipher the mechanisms by which palmitoylation regulates neurotrophic transport and restore neuronal homeostasis in Huntington disease.


Huntington’s disease (HD) is caused by the abnormal polyglutamine expansion in the N-ter part of huntingtin (HTT), a large protein of 350kDa. Over the past years, we proposed that HTT acts a scaffold for the molecular motors and through this function, regulates the axonal transport of vesicles containing the Brain-derived neurotrophic factor BDNF in neurons. This function is altered in HD. We recently identified palmitoylation as a therapeutic target for HD. We want to decipher the mechanism by which palmitoylation restores axonal transport and neuronal homeostasis in vitro and in vivo with the objective of developing a drug candidate for this devastating and yet incurable disease.


Techniques used will include molecular biology, biochemistry, primary cultures, state of the art live-imaging microscopy, the use of microfluidic devices to study intracellular dynamics in connected neuronal networks as well as mouse work (behavior, biochemistry, histochemistry, brain clearing.



Domaines d'expertise requis

Neurobiology, imaging techniques, microfluidics, HD mice, behavior


Frédéric Saudou (PUPH UGA) / Laura Auboyer (Postdoc UGA)
Email :
Phone : +33 4 56 52 05 14


Mise à jour le 8 juillet 2022


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