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Grenoble Institut des Neurosciences Grenoble Institut des Neurosciences

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Palmitoylation as a new therapeutic approach for curing Huntington disease

Objectifs

The objectives of the project are to decipher the mechanisms by which palmitoylation regulates neurotrophic transport and restore neuronal homeostasis in Huntington disease.
 

Résumé

Huntington’s disease (HD) is caused by the abnormal polyglutamine expansion in the N-ter part of huntingtin (HTT), a large protein of 350kDa. Over the past years, we proposed that HTT acts a scaffold for the molecular motors and through this function, regulates the axonal transport of vesicles containing the Brain-derived neurotrophic factor BDNF in neurons. This function is altered in HD. We recently identified palmitoylation as a therapeutic target for HD. We want to decipher the mechanism by which palmitoylation restores axonal transport and neuronal homeostasis in vitro and in vivo with the objective of developing a drug candidate for this devastating and yet incurable disease.
 

Méthodes

Techniques used will include molecular biology, biochemistry, primary cultures, state of the art live-imaging microscopy, the use of microfluidic devices to study intracellular dynamics in connected neuronal networks as well as mouse work (behavior, biochemistry, histochemistry, brain clearing.
 

Références

 

Domaines d'expertise requis

Neurobiology, imaging techniques, microfluidics, HD mice, behavior
 

Contacts

Frédéric Saudou (PUPH UGA) / Laura Auboyer (Postdoc UGA)
Email : frederic.saudou@univ-grenoble-alpes.fr
Phone : +33 4 56 52 05 14

Téléchargement(s)

Mise à jour le 8 juillet 2022

Contacts

Pour les stages (master, licence, 3ème hors sessions décembre et avril), envoyer directement un email au responsable de l'équipe que vous avez identifiée.

Pour une candidature spontanée pour un emploi et uniquement pour cela, envoyez un email à gincomm[at]univ-grenoble-alpes.fr ou utilisez le formulaire de contact.

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