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Deciphering the gene-environment interaction in neuronal aging and Parkinson’s disease

Objectifs

The goal of this study is to identify genetic and environmental cues driving the senescence of neurons in both healthy aging and in the context of Parkinson’s disease.

Résumé

Aging is the greatest risk factor for developing neurodegenerative disorders including Parkinson’s disease. Everyone ages differently and the quality of our cerebral functions is conditioned by the intricate interaction of our genetic background and the exposure to environmental cues. The identification of these factors and the study of their contribution is essential to better understand brain aging and to possibly explain the development of sporadic forms of Parkinson. However, to date, this key question remains understudied mostly because of inter-individual differences in both healthy and pathological aging.

Méthodes

The M2 student will perform the following techniques: cell culture, neuronal culture preparations, tissue extraction, immunostaining, microscopy, image analysis, protein dosage, and western blot, senescence assays, bioinformatics, RNA-sequencing.

Références

Tamburrino A, Decressac M. (2016) Aged and diseased neurons get lost in transport, Trends Neurosci., 39(4):199-201

Dehay et al. (2020) Targeting alpha-synuclein: therapeutic options, Mov. Disord., 31(6):882-8.

Domaines d'expertise requis

No specific prior expertise is needed. The student will learn what is new for her/him.

Contacts

M. Decressac (Inserm Researcher/Group leader)
Email : Michael.Decressac@inserm.fr
Phone : 04.56.52.06.75

Téléchargement(s)

GIN_offre-stage-M2_2022-2023_MDecressac-1_20220707.pdf (PDF, 154590 Ko)

Mise à jour le 8 juillet 2022

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Contacts

Pour les stages (master, licence, 3ème hors sessions décembre et avril), envoyer directement un email au responsable de l'équipe que vous avez identifiée.

Pour une candidature spontanée pour un emploi et uniquement pour cela, envoyez un email à gincomm[at]univ-grenoble-alpes.fr ou utilisez le formulaire de contact.