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Grenoble Institut des Neurosciences Grenoble Institut des Neurosciences

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Control axon connectivity during central nervous system regeneration

Objectifs

The aim of this project is to understand mechanisms of central nervous system regeneration and circuit connectivity to ensure functional recovery.
 

Résumé

Over the past few years, researchers have started to unfold the molecular mechanisms underlying central nervous system regeneration. Using modulation of pro-growth pathways, lesioned axons can regenerative past the injury site and grow over few millimeters. However, one major roadblock remains: how to form functional circuit? To answer this question, we will a combination of molecular and cellular approaches to find new mechanism to ensure axon growth and axon guidance in mature central nervous system.
This project will use state of the art molecular biology, cellular biology, in vivo models of central nervous system regeneration (in mice) and imaging.
 

Méthodes

Molecular biology (cloning, PCR); cell culture (cell lines, primary neuron culture, explant culture), microscopy (confocal, spinning disk, light sheet, epifluorescence), histology (cryosection, immunostaining, in situ hybridization), optic nerve surgeries.
 

Références

  • Vilallongue N, Schaeffer J, Hesse AM, Delpech C, Paccard A Couté Y, Belin S, Nawabi H. Axon guidance modalities in CNS regeneration revealed by quantitative proteomic analysis. BioRxive (doi: https://doi.org/10.1101/2021.03.26.437129 ; in revision at Nature Communication)
  • SchaefferJ*, Delpech C*, Albert F, Belin S, Nawabi H. Adult mouse retina explants: an ex vivo window to explore central nervous system diseases. * co first autors; co-lead. Frontiers in Molecular Neuroscience 2020
 

Domaines d'expertise requis

molecular biology, neuroscience, cell biology, genetics, biochemistry, histology
 

Contacts

H. Nawabi (CR Inserm)
Email : homaira.nawabi@univ-grenoble-alpes.fr
Phone : +33-4-56-52-06-50

Téléchargement(s)

Mise à jour le 8 juillet 2022

Contacts

Pour les stages (master, licence, 3ème), envoyer directement un email au responsable de l'équipe que vous avez identifiée.

Pour une candidature spontanée pour un emploi et uniquement pour cela, envoyez un email à gincomm[at]univ-grenoble-alpes.fr ou utilisez le formulaire de contact.

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