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Grenoble Institut des Neurosciences Grenoble Institut des Neurosciences

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Characterization of neuro-adaptatifs mechanisms in the parabrachial nucleus in a rat model of Parkinson’s disease

Objectifs

Our aim is to characterize the cellular and molecular re-organisation of the Parabrachial nucleus in a rat model of Parkinson’s disease.

Résumé

Parkinson’s disease (PD) is a neurodegenerative disease characterized by a progressive loss of dopaminergic neurons localized in the substantia nigra pars compacta. This dopaminergic loss causes the dysfunction of a group of subcortical structures called the basal ganglia. PD is classically associated to motor disturbances, however, it is now recognized that this disease is also associated to numerous non-motor symptoms, including pain. This project aims to analyze new plasticity mechanisms in two rat models of Parkinson’s disease, that may underlie some abnormal pain symptoms observed in PD. A first series of electrophysiological experiments performed in our team show that the parabrachial nucleus, a key structure from the brainstem processing pain information, could present a neuro-adaptation with the degree of dopaminergic lesion. It is now crucial to complete our physiological data with neuro-anatomical, cellular and molecular markers of compensatory phenomenon possibly occurring in our rat models of the disease.

Méthodes

These experiments will be done in three groups of rats: a control group and two groups of rats with a partial or total dopaminergic lesions of the substantia nigra pars compacta. We will analyze the morphology of the parabrachial nucleus neurons with a golgi technique and the quantity of Glutamate and GAB receptors using a technique of Western blot.

Références

  • Pautrat A, Rolland M, Barthelemy M, Baunez C, Sinniger V, Piallat B, Savasta M, , Overton P.G, David O and Coizet V (submitted) Pain and the subthalamic nucleus: revealing a novel nociceptive network
  • Rolland M., Carcenac C., Overton P.G., Savasta M. and Coizet V. (2013), Enhanced visual responses in the superior colliculus and subthalamic nucleus in an animal model of Parkinson's disease, Neuroscience, 12;252:277-88

Contacts

Coizet V
Email : veronique.coizet@univ-grenoble-alpes.fr
Phone : 04 56 52 06 88
Mise à jour le 21 juin 2018

Contacts

Pour une candidature spontanée, envoyez un email à gincomm[at]univ-grenoble-alpes.fr ou utilisez le formulaire de contact.

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