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Grenoble Institut des Neurosciences Grenoble Institut des Neurosciences

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Postdoctoral position in Stephane Belin’s team, Grenoble Institute Neurosciences, France

Central Nervous system (CNS) neurons are not able to regenerate after injury, leading to irreversible loss of cognitive and motor functions. Today, no treatments are available to help patients after traumatic or chronic injuries like neurodegenerative diseases. This represent a huge challenge for medicine and society. The goal of the postdoctoral project is to determine the role of the translational complex on translation regulation to explore new mechanisms of neuroprotection and/or neuronal regeneration.

Qualification: We seek an enthusiastic, highly motivated post-doctoral fellow to work on translation regulation and mechanisms of axon degeneration/regeneration in the visual system. The candidate needs to hold a PhD with good record of publications but with no more than 2 years after getting PhD. Candidate needs a strong background in molecular biology and biochemistry with knowledge in RNAseq. Additional knowledge in mouse handling and microscopy is a plus. We offer a close supervision in a motivated team and a stimulating scientific environment.
Location: The laboratory is part of the GIN Grenoble Institute of Neurosciences, at Inserm and Grenoble Alpes University research center devoted to understanding brain functions in health and diseases. The GIN is composed of research teams specialized in the study of physiological processes or in pathologies of the nervous system and in the development of innovating techniques to explore them and provides with the state-of-the-art platforms and technologies. The GIN is founder member of the Grenoble center of excellence in neurodegenerative disorders (GREEN). Grenoble is an active research city in France located three hours from Paris by train.

Refs: Evidence for rRNA 2'-O-methylation plasticity: Control of intrinsic translational capabilities of human ribosomes. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12934-12939. doi: 10.1073/pnas.1707674114. Epub 2017 Nov 20.,Injury-induced decline of intrinsic regenerative ability revealed by quantitative proteomics. Neuron. 2015 May 20;86(4):1000-14. p53 acts as a safeguard of translational control by regulating fibrillarin and rRNA methylation in cancer. Cancer Cell. 2013 Sep 9;24(3):318-30.

How to apply:
Candidates should email a cover letter, a CV and at least two reference letters to:
Stephane Belin,
Mise à jour le 23 juillet 2021


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