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Post-doc position in neuro oncology image analysis

Postdoctoral fellowship in neuro oncology image analysis

 

Glioblastoma multiforme (GBM) is a lethal disease because of a constant relapse. Among the salvage treatments, hypofractionnated stereotactic reirradiation (hFSRT) is one of the main options. Because irradiation induces a vaccine effect, a partner to this project (team of Elizabeth Moyal based in Toulouse) designed and developed a national PhaseI/II clinical trial randomizing hFSRT versus hFSRT associated with the anti-PDL1 Durvalumab. This trial includes a longitudinal follow-up of patients by multiparametric MR imaging.

 

The aim of this project is to find predictive imaging biomarkers able to i) discriminate between tumor progression and pseudoprogression and ii) to early detect local tumor relapse in the context of hSFRT and Durvalumab treatment combination. This project will imply to use the most advanced image analysis approaches to automatically extract imaging biomarkers from multiparametric MRI dataset. In the context of MRI and GBMs, the most promising image analyses techniques to quantify the evolution of the intra-tumor heterogeneity are the voxel-by-voxel, the cluster, the texture (Radiomics approaches) and the deep learning analyses.

 

The successful applicant will have a strong expertise in MR imaging and image analysis, Python and Matlab programming skills are key prerequisites. Knowledge in brain physiopathology will also be strongly valued. The candidate should be fluent in English (and preferably in French which will be the working language), have a good communication skills and organizational skills and a PhD in a relevant area. Candidates are expected to be highly motivated and to work independently with a strong work ethic. Applications including a cover letter, a detailed CV including a publication list and contacts of up to three referees should be sent as soon as possible.

 

The candidate will be based in Grenoble, but the project will be supervised by two mentors: Benjamin Lemasson (Grenoble) and Soléa Ken (Toulouse). Due to this collaboration, the candidate will have to travel occasionally to Toulouse.

 

Key words: Glioblastomas, MRI, Radiomics, Voxel-based, Cluster analysis and Deep learning analyses

 

Location             Grenoble Institute of Neurosciences, Grenoble, France

Contract:            Between 30 and 36 months (depending of experience), start April 1st 2019

Salary                 Depending of experiences and according to Inserm Grid

Funds                 Fondation ARC; programme SIGN’IT ; project SI2GMA

Contact               Both benjamin.lemasson@univ-grenoble-alpes.fr and Ken.Soleakhena@iuct-oncopole.fr


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Mise à jour le 11 janvier 2019

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Pour une candidature spontanée, envoyez un email à gincomm[at]univ-grenoble-alpes.fr ou utilisez le formulaire de contact.

Pour les stages de licence et de 3ème, voir les modalités de demande spécifiques sur les pages correspondantes. 

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