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Human Brain Project funded postdoctoral position, Grenoble Institute Neurosciences, France

Context

The human brain project (www.humanbrainproject.eu) is building a research infrastructure to help advance neuroscience, medicine, and computing. It is one of four FET (Future and Emerging Technology) Flagships, the largest scientific projects ever funded by the European Union. For its last funding period (2020-2023), in addition to the development of a common platform called EBRAINS (ebrains.eu), brain science is being distributed into 3 scientific work packages (WPs).

This postdoc takes place in the Task “Multiscale models of brain responsiveness: from single cells to the whole brain” of WP2 “Networks underlying brain cognition and consciousness”. The main objective of the Task is to model the responsiveness and large-scale spatiotemporal spread of information in different brain states in humans, using integration of experimental data and computational models during brain state transitions. To test and optimize brain models already developed in HBP, several animal and human experiments will be conducted.

At the Grenoble Institute of Neuroscience, we will investigate brain responsiveness in rodents using sensory stimuli presented under different brain states. To this aim, we will primarily use rodent models showing transient alterations of brain states and perform the acquisition of fMRI/EEG data. This project will be developed in close partnership with Paris-Saclay Institute of Neuroscience (Alain Destexhe, neuro-psi.cnrs.fr), who develops brain models aiming at reproducing both EEG and fMRI features.

 

Roadmap

The goal is to study brain responsiveness using functional MRI. Anatomical connectivity using diffusion MRI, resting-state functional connectivity, physiological status, and scalp EEG will also be recorded. Sensory stimulus (e.g. whiskers deflection, visual stimulation) will be used to elicit brain activation.

The following roadmap is proposed:

(i) Set-up MRI-EEG acquisitions. Based on existing tools and know-how at the Grenoble Institute of Neuroscience (1), optimize the acquisition protocol.

(ii) Data collection in several animal models. The first model will be the GAERS rat (Genetic Absence Epilepsy Rat from Strasbourg (2)), an epilepsy absence model with regular spiking activity. This model will allow the acquisition of brain response to whisker stimulation in various brain states. Other animal models will be provided by HBP partners during the course of the project.

(iii) Evaluate how brain responsiveness depends on on-going brain activity, using resting-state fMRI, fMRI responses to stimulation, and EEG data.

The successful candidate should have a Ph.D. in neuroscience, or related field, and a strong interest for imaging data processing. Experience in preclinical studies and/or MRI or EEG data processing will be appreciated.

Contact: send CV and motivation letter to team « Functional Neuroimaging and Brain Perfusion » Emmanuel Barbier (emmanuel.barbier@univ-grenoble-alpes.fr) and team « Brain Stimulation and Systems Neuroscience » Olivier David (olivier.david@inserm.fr)

Location: Grenoble Institute Neurosciences, https://neurosciences.univ-grenoble-alpes.fr

Start date: Fall 2020 – Contract duration: 1 year, renewable once.

Références:

(1)  G. J.-P. C. Becq, T. Habet, N. Collomb, M. Faucher, C. Delon-Martin, V. Coizet, S. Achard, E. L. Barbier. Functional connectivity is preserved but reorganized across several anesthetic regimes. Neuroimage, In Press.
(2)  
Depaulis A, David O and Charpier S (2016). The genetic absence epilepsy rat from Strasbourg as a model to decipher the neuronal and network mechanisms of generalized idiopathic epilepsies. J Neurosci. Methods 260, 159-174



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Mise à jour le 13 mai 2020

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