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Grenoble Institut des Neurosciences Grenoble Institut des Neurosciences

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ERC-Funded Post-doc Position in Neurosciences, Grenoble, France

Fast axonal transport (FAT) of brain-derived neurotrophic factor (BDNF) is essential for brain function. It depends on huntingtin (HTT), the protein that when mutated causes Huntington’s disease (HD), a devastating and still incurable disorder. BDNF is regulated by neuronal activity and its transport requires energy. Yet we do not know if FAT of BDNF is regulated by neuronal activity and if HTT facilitates activity-dependent transport. The energy sources for FAT of BDNF and their regulation by activity remain unclear, as do the exact mechanisms of BDNF transport reduction in the HD-causing mutation.

The objective is to understand how neuronal activity regulates intra-axonal dynamics of BDNF and synapse function using microfluidics systems connected to multielectrode arrays. Experiments will include the study, using live imaging and biosensors, of specific signaling pathways and energy sources and how these adapt to high neuronal demands. The lab is expert in such approaches (Cell Reports 2018) and has recently shown the importance of glycolysis to provide energy for FAT (Cell 2013, Nat Comm 2016). The success of this project may provide understanding of basic mechanisms of transport and potential new therapeutics targets and strategies for Huntington’s diseases and others degenerative disorders (Science Advances 2021, Cell Report 2021, Embo Mol Med 2020, eLife 2020).

This multidisciplinary project will involve neuronal cell biology & state-of-the-art imaging techniques, the development of new microfluidic devices and their coupling to multi-electrode arrays to induce neuronal activity within brain-on-a-chip networks and, computational modeling.

We are seeking a highly motivated scientist with less than 2 years of postdoctoral experience. Experience in cellular biology is required. Additional knowledge in neurological disorders would be a bonus. This ERC-funded position is open from now to June 2022.

The laboratory is part of the Grenoble Institute of Neurosciences GIN, a research center devoted to understanding brain functions in health and diseases. The GIN is founder member of the Grenoble center of excellence in neurodegenerative disorders (CoEN GREEN) and member of the IDEX NeuroCoG. Grenoble is an active research city in France located in the French Alps three hours from Paris by train.

Candidates should apply by sending a CV, a brief outline of current research, scientific interests and career goals, as well as the name and contact details of at least two academic references to


Mise à jour le 9 septembre 2021


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