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Grenoble Institut des Neurosciences Grenoble Institut des Neurosciences

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Page personnelle de Antoine Depaulis

Membre de

GIN - Équipe "Synchronisation et modulation des réseaux neuronaux dans l'épilepsie"

Informations de contact

Bureau principal

Bureau principal
1/074
Tél. 
04 56 52 06 65
Fax 
04 56 52 06 69

Fonctions et responsabilités

INSERM Research Director and Group leader at Grenoble Institute of Neuroscience

Curriculum vitae

Since 1980, my field of expertise has mainly involved integrative Neuroscience and has aimed at characterizing the neural circuits of brain pathologies like the epilepsies.

Since 1994, my work has been focused on the characterization of circuits that generate or control epileptic seizures. This research has required the development of two original models of chronic epilepsy that I characterized with my group : (i) the « Genetic Absence Epilepsy Rat from Strasbourg » (GAERS) and (ii) the mouse model of mesiotemporal lobe epilepsy (MTLE mouse), induced in mice by an intrahippocampal injection of kainate.

The research of my team in Strasbourg, and then Grenoble (since 2003), has contributed to the demonstration that the thalamo-cortical circuit is involved in the generation of absence seizures in GAERS. More recently we have demonstrated the critical role of the anterior part of the somatosensory cortex in absence seizure initiation in GAERS and their development during cortical maturation.

Similarly, we have characterized, within the hippocampus, some of the neuroplasticity processes (BDNF, Reelin, glial cells, microglia) that are involved in the development of an aberrant neural and astroglial network that generate focal seizures in the MTLE mouse.

We have also demonstrated the role of the basal ganglia and dopamine in the control of epileptic seizures. This was validated in different animal models, as well as in some epileptic patients, in collaboration with clinicians. It constitutes the rationale background of deep brain stimulations of the substantia-nigra for the treatment of drug-resistant forms of epilepsies that cannot be treated by resective surgery.

Since 1982, my work has generated 165 articles in peer-reviewed international journals, up to 30 book chapters and up to 100 conferences. These publications are regularly cited (Total citations = 8,560; H index =53, as of April 2018).

I have supervised 26 PhD students and postdocs since 1980.

I have obtained 25 different research grants (ANR, Europe, FUI, Region, Foundations) since  1990 and have been the principal investigator for 16 of them.  

Links


English biosketch : www.dropbox.com/s/ca8naga17grn3ic/CV_Depaulis_Short_Brit.pdf
LinkedIn : https://fr.linkedin.com/in/antoinedepaulis

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