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Cracking the (tubulin) code of mitosis

on the February 27, 2020
11:30

Seminar by Helder Maiato (Chromosome Instability & Dynamics Lab, Universidade do Porto, Portugal)

Similar to the “histone code” hypothesis in which epigenetic marks on histone tails expand the information potential of the genetic code, different tubulin isoforms, combined with a panoply of post-translational modifications (PTMs), constitute the so-called “tubulin code”. The tubulin code was proposed to account for subcellular differentiation of distinct microtubule populations that control the activity of several molecular motors. One of these PTMs consists in the catalytic removal of the C-terminal tyrosine of most mammalian alpha-tubulin isoforms by tubulin carboxypeptidases (TCPs), such as the recently identified Vasohibin-SVBP complexes, followed by re-tyrosination of soluble alpha-tubulin by tubulin tyrosine ligase (TTL). alpha-tubulin detyrosination has been recently implicated in mitosis and meiosis, neuronal processes and cognitive brain function, heart and skeletal muscle contraction, and cancer. In this seminar, I will discuss our work aiming to elucidate how the tubulin code regulates different aspects behind faithful chromosome segregation during mitosis and the implications for human cancers. In particular, I will focus on recent evidence that support that alpha-tubulin detyrosination works simultaneously as a navigation system and as a “mitotic error code” to ensure mitotic fidelity.

Host : Marie-Jo Moutin.

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