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Astrocytes-derived L-serine: a key signaling pathway

on the November 23, 2017
11:30

Seminar by Gilles Bonvento (MIRCEN, CEA - CNRS, Fontenay-aux-Roses)

Astrocytes predominantly process glucose glycolytically. Aside from ATP production, a major function of glycolysis is to provide precursors such as L-serine, to support macromolecular synthesis. In the brain, L-serine serves as the precursor of D-serine, the principal co-agonist of synaptic N-methyl D-aspartate receptors (NMDAR).  I will  present experimental data obtained in both human and mice indicating that the biosynthesis of L-serine is of paramount importance in the healthy and diseased (Alzheimer) brain.


Hosts: Mireille Albrieux and Alain Buisson.

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Serge Kampf amphitheatre
Updated on September 12, 2017

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