Content

x

Search in this site

Grenoble Institut des Neurosciences Grenoble Institut des Neurosciences

  • Linkedin
  • Twitter
  • Youtube

Home > Join us > Master internships

See the complete sitemap

Energy metabolism as a regulator of axonal transport in health and Huntington’s disease

Objectives

The objectives of the project are to understand the role of the huntingtin protein in the regulation of intracellular dynamics in neurons and its relation to energy metabolism
 

Abstract

Huntington’s disease (HD) is caused by the abnormal polyglutamine expansion in the N-ter part of huntingtin (HTT), a large protein of 350kDa. Over the past years, we proposed that HTT acts a scaffold for the molecular motors and through this function, regulates the efficiency of vesicular transport along microtubules in neurons. Huntingtin also scaffolds glycolytic enzymes that provide energy for axonal transport. Here we propose to study the sources of energy for axonal transport in response to neuronal activity and the role of HTT in this mechanism in both normal and Huntington’s disease conditions.
 

Methods

Techniques used will include molecular biology, biochemistry, primary cultures, state of the art live-imaging microscopy and the development and use of new microfluidic devices to study intracellular dynamics in connected neuronal networks.
 

References


Requested domains of expertise

Cell biology, neurobiology, imaging techniques, microscopy, microfluidics

Contacts

Frédéric Saudou, Prof, PU-PH, UGA-CHUGA
Email : frederic.saudou@univ-grenoble-alpes.fr
Phone : +33 4 56 52 05 14
 

Téléchargement(s)

Updated on June 24, 2021

Membres
Associés renforcés
Associés simples