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From rat to primate: modeling of white matter

on the March 8, 2017

3D model of the topographical organization of prefrontal descending pathways

Psychiatric diseases are linked to abnormalities in specific white matter (WM) pathways, and the efficacy of deep brain stimulation relies upon activation of WM. Experiments in rodents are necessary for studying the mechanisms of brain function.

However, the translation of results between primates to rodents is hindered by the fact that the organization of descending WM in rodents is poorly understood. This is especially relevant for the prefrontal cortex, abnormal connectivity of which is central to psychiatric disorders.

Researchers from the team "Brain Stimulation and Systems Neuroscience" have therefore studied the organization of descending rodent prefrontal pathways.

These fibers course through a subcortical structure, the striatum, and share important organization principles with primate WM. These results allow to effectively model primate WM in the rodent.

3D model of the topographical organization of Prefrontal descending pathways. Each color codes for a different injection site, with the cingulate cortex in blue, the prelimbic cortex in orange, the infralimbic cortex in red and the ventral orbital cortex in green.

Coizet V, Heilbronner SR, Carcenac C, Mailly P, Lehman JF, Savasta M, David O, Deniau JM, Groenewegen HJ, Haber SN (2017). Organization of the Anterior Limb of the Internal Capsule in the Rat. J Neurosci. 2017 Mar 8;37(10):2539-2554.

Updated on December 8, 2017

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