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Grenoble Institut des Neurosciences Grenoble Institut des Neurosciences

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le 30 juin 2017

Cortical Phase-Amplitude Coupling in a Progressive Model of Parkinsonism in Non-Human Primates Séminaire d'Annaëlle Devergnas (Emory University, Atlanta, USA)

Parkinson’s disease is associated with abnormal oscillatory activities throughout the basal ganglia-thalamocortical network. In the electrocorticogram of patients with advanced parkinsonism, the amplitude of gamma-band oscillations has been shown to be abnormally coupled to the phase of beta band. It is not known when in the course of the disease this abnormal phase-amplitude coupling arises, and whether it is influenced by arousal or prior exposure to dopaminergic medications. To address these issues, we analyzed the relationship between phase-amplitude coupling and motor impairment in a progressive primate model of parkinsonism. Phase-amplitude coupling was measured in electrocorticograms from the primary motor cortex and the supplementary motor area in three monkeys. We found that parkinsonism was associated with increased coupling between the phase of low-frequency (4-10Hz) oscillations and the amplitude of oscillations in the high gamma band (50-150Hz). These changes only reached significance when the animals became fully parkinsonian and were normalized after levodopa treatment. We also found a similar increase in phase-amplitude coupling during sleep of normal animals. The identified phase-amplitude coupling was independent of concomitant changes in spectral power. We conclude that phase-amplitude coupling is predominately a sign of advanced parkinsonism, and is, thus, not essential for the development of parkinsonism.

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GIN, Amphi Serge Kampf


Grenoble - Campus Santé

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